Aspulvinone O

Aspulvinone O is a selective inhibitor of glutamate oxaloacetate aminotransferase GOT1. Aspulvinone O inhibits glutamine metabolism and reduces NADPH production, thereby inducing oxidative stress and apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. Aspulvinone O inhibits PDAC cell proliferation in vitro and tumor growth in xenograft models[1][2].

Product Specifications

CAS Number

[914071-54-8]

UNSPSC

12352005

Target

Aminotransferases (Transaminases) ; Apoptosis

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aspulvinone-o.html

Purity

96.0

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OC1=C(C2=CC(C/C=C(C)/C)=C(O)C=C2O)C(O/C1=C/C3=CC(C/C=C(C)/C)=C(O)C=C3)=O

Molecular Formula

C27H28O6

Molecular Weight

448.51

References & Citations

[1]Sun W, et al. Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. Cell Commun Signal. 2019;17 (1) :111.|[2]Yan S, et al. Discovery of GOT1 Inhibitors from a Marine-Derived Aspergillus terreus That Act against Pancreatic Ductal Adenocarcinoma. Mar Drugs. 2021 Oct 20;19 (11) :588.