Propylparaben (sodium)

Propylparaben sodium (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria. Propylparaben sodium is prevalently used in cosmetics, pharmaceuticals, and foods. Propylparaben sodium disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways. Propylparaben sodium also decreases sperm number and motile activity in rats[1][2][3].

Product Specifications

CAS Number

[35285-69-9]

Product Name Alternative

Propyl parahydroxybenzoate (sodium) ; Propyl 4-hydroxybenzoate (sodium)

UNSPSC

12352005

Hazard Statement

H318, H401

Target

Apoptosis; Bacterial; Endogenous Metabolite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/propylparaben-sodium.html

Purity

99.03

Solubility

10 mM in DMSO

Smiles

O=C(OCCC)C1=CC=C(O[Na])C=C1

Molecular Formula

C10H11NaO3

Molecular Weight

202.18

Precautions

H318, H401

References & Citations

[1]S Oishi, et al. Effects of propyl paraben on the male reproductive system. Food Chem Toxicol. 2002 Dec;40 (12) :1807-13.|[2]Gal A, et, al. Propylparaben inhibits mouse cultured antral follicle growth, alters steroidogenesis, and upregulates levels of cell-cycle and apoptosis regulators. Reprod Toxicol. 2019 Oct;89:100-106.|[3]Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products. Int J Toxicol. 2008;27 Suppl 4:1-82.