Casuarictin

Casuarictin is a potent and competitive α-glucosidase inhibitor with an IC50 of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research[1].

Product Specifications

CAS Number

[79786-00-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Glycosidase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/casuarictin.html

Purity

98.62

Solubility

10 mM in DMSO

Smiles

O=C1OC[C@H]2O[C@@H](OC(C3=CC(O)=C(O)C(O)=C3)=O)[C@H](OC(C4=CC(O)=C(O)C(O)=C45)=O)[C@@H](OC(C6=C5C(O)=C(O)C(O)=C6)=O)[C@@H]2OC(C7=CC(O)=C(O)C(O)=C7C8=C1C=C(C(O)=C8O)O)=O

Molecular Formula

C41H28O26

Molecular Weight

936.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Rupali Kumari, et al. Casuarictin: A new herbal drug molecule for Alzheimer's disease as inhibitor of presenilin stabilization factor like protein. Heliyon. 2020 Nov 21;6 (11) :e05546. |[2]Yang Xu, et al. Identification of a novel α-glucosidase inhibitor from Melastoma dodecandrum Lour. fruits and its effect on regulating postprandial blood glucose. Food Chem. 2023 Jan 15:399:133999.