Casuarictin
Casuarictin is a potent and competitive α-glucosidase inhibitor with an IC50 of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research[1].
Product Specifications
CAS Number
[79786-00-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Glycosidase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/casuarictin.html
Purity
98.62
Solubility
10 mM in DMSO
Smiles
O=C1OC[C@H]2O[C@@H](OC(C3=CC(O)=C(O)C(O)=C3)=O)[C@H](OC(C4=CC(O)=C(O)C(O)=C45)=O)[C@@H](OC(C6=C5C(O)=C(O)C(O)=C6)=O)[C@@H]2OC(C7=CC(O)=C(O)C(O)=C7C8=C1C=C(C(O)=C8O)O)=O
Molecular Formula
C41H28O26
Molecular Weight
936.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Rupali Kumari, et al. Casuarictin: A new herbal drug molecule for Alzheimer's disease as inhibitor of presenilin stabilization factor like protein. Heliyon. 2020 Nov 21;6 (11) :e05546. |[2]Yang Xu, et al. Identification of a novel α-glucosidase inhibitor from Melastoma dodecandrum Lour. fruits and its effect on regulating postprandial blood glucose. Food Chem. 2023 Jan 15:399:133999.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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