D-Psicose

D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease[1][2][3][4][5].

Product Specifications

CAS Number

[551-68-8]

Product Name Alternative

D-Allulose

UNSPSC

12352200

Hazard Statement

H314, H318

Target

NF-κB; p38 MAPK

Type

Biochemical Assay Reagents

Related Pathways

MAPK/ERK Pathway; NF-κB

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/d-psicose.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC[C@H]([C@H]([C@H](C(CO)=O)O)O)O

Molecular Formula

C6H12O6

Molecular Weight

180.16

Precautions

H314, H318

References & Citations

[1]Murao K, et al. D-Psicose inhibits the expression of MCP-1 induced by high-glucose stimulation in HUVECs. Life Sci. 2007 Jul 26;81 (7) :592-9.|[2]Hossain A, et al. Rare sugar D-psicose protects pancreas β-islets and thus improves insulin resistance in OLETF rats. Biochem Biophys Res Commun. 2012 Sep 7;425 (4) :717-23. |[3]Baek SH, et al. D-psicose, a sweet monosaccharide, ameliorate hyperglycemia, and dyslipidemia in C57BL/6J db/db mice. J Food Sci. 2010 Mar;75 (2) :H49-53. |[4]Tan J, et al. D-Psicose mitigates NAFLD mice induced by a high-fat diet by reducing lipid accumulation, inflammation, and oxidative stress. Front Nutr. 2025 May 27;12:1574151. |[5]Zeng Y, et al. Dietary D-psicose, a rare sugar, shows no modifying effects in a medium-term liver carcinogenesis bioassay in F344 male rats. Journal of toxicologic pathology, 2005, 18 (2) : 85-88.