D-Psicose
D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease[1][2][3][4][5].
Product Specifications
CAS Number
551-68-8
Product Name Alternative
D-Allulose
UNSPSC
12352200
Hazard Statement
H314, H318
Target
NF-κB; p38 MAPK
Type
Biochemical Assay Reagents
Related Pathways
MAPK/ERK Pathway; NF-κB
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/d-psicose.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
OC[C@H]([C@H]([C@H](C(CO)=O)O)O)O
Molecular Formula
C6H12O6
Molecular Weight
180.16
Precautions
H314, H318
References & Citations
[1]Murao K, et al. D-Psicose inhibits the expression of MCP-1 induced by high-glucose stimulation in HUVECs. Life Sci. 2007 Jul 26;81 (7) :592-9.|[2]Hossain A, et al. Rare sugar D-psicose protects pancreas β-islets and thus improves insulin resistance in OLETF rats. Biochem Biophys Res Commun. 2012 Sep 7;425 (4) :717-23. |[3]Baek SH, et al. D-psicose, a sweet monosaccharide, ameliorate hyperglycemia, and dyslipidemia in C57BL/6J db/db mice. J Food Sci. 2010 Mar;75 (2) :H49-53. |[4]Tan J, et al. D-Psicose mitigates NAFLD mice induced by a high-fat diet by reducing lipid accumulation, inflammation, and oxidative stress. Front Nutr. 2025 May 27;12:1574151. |[5]Zeng Y, et al. Dietary D-psicose, a rare sugar, shows no modifying effects in a medium-term liver carcinogenesis bioassay in F344 male rats. Journal of toxicologic pathology, 2005, 18 (2) : 85-88.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Frequently Asked Questions
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