Human TWEAK Protein (Highly Pure)

<strong>Human TWEAK Protein </strong>_x000D_ <strong>Catalog number:</strong> B2010373_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Human TWEAK Protein expressed in CHO. This protein acts as an apoptosis inducer via multiple pathways of cell death in a cell type-specific manner as well as a promoter of proliferation and migration of endothelial cells._x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> rHuTWEAK; TNF-related weak inducer of apoptosis; TNFSF12; DR3LG; APO3L_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Hu G, Zeng W, Xia Y. TWEAK/Fn14 signaling in tumors. Tumour Biol. 2017_x000D_ Jun;39(6):1010428317714624._x000D_ _x000D_ 2: Liu Q, Xiao S, Xia Y. TWEAK/Fn14 Activation Participates in Skin_x000D_ Inflammation. Mediators Inflamm. 2017;2017:6746870._x000D_ _x000D_ 3: Croft M, Siegel RM. Beyond TNF: TNF superfamily cytokines as targets for the_x000D_ treatment of rheumatic diseases. Nat Rev Rheumatol. 2017 Apr;13(4):217-233._x000D_ _x000D_ 4: Arriens C, Wren JD, Munroe ME, Mohan C. Systemic lupus erythematosus_x000D_ biomarkers: the challenging quest. Rheumatology (Oxford). 2017 Apr_x000D_ 1;56(suppl_1):i32-i45._x000D_ _x000D_ 5: Escoté X, Gómez-Zorita S, López-Yoldi M, Milton-Laskibar I, Fernández-_x000D_ Quintela A, Martínez JA, Moreno-Aliaga MJ, Portillo MP. Role of Omentin, Vaspin,_x000D_ Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development. Int J_x000D_ Mol Sci. 2017 Aug 15;18(8):1770._x000D_ _x000D_ 6: Bernardi S, Voltan R, Rimondi E, Melloni E, Milani D, Cervellati C, Gemmati_x000D_ D, Celeghini C, Secchiero P, Zauli G, Tisato V. TRAIL, OPG, and TWEAK in kidney_x000D_ disease: biomarkers or therapeutic targets? Clin Sci (Lond). 2019 May_x000D_ 16;133(10):1145-1166._x000D_ _x000D_ 7: Vincent C, Findlay DM, Welldon KJ, Wijenayaka AR, Zheng TS, Haynes DR,_x000D_ Fazzalari NL, Evdokiou A, Atkins GJ. Pro-inflammatory cytokines TNF-related weak_x000D_ inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein_x000D_ kinase (MAPK)-dependent expression of sclerostin in human osteoblasts. J Bone_x000D_ Miner Res. 2009 Aug;24(8):1434-49._x000D_ _x000D_ 8: Meyer T, Amaya M, Desai H, Robles-Carrillo L, Hatfield M, Francis JL,_x000D_ Amirkhosravi A. Human platelets contain and release TWEAK. Platelets._x000D_ 2010;21(7):571-4._x000D_ _x000D_ 9: Martínez-Miguel P, Medrano-Andrés D, Griera-Merino M, Ortiz A, Rodríguez-_x000D_ Puyol M, Rodríguez-Puyol D, López-Ongil S. Tweak up-regulates endothelin-1_x000D_ system in mouse and human endothelial cells. Cardiovasc Res. 2017_x000D_ Feb;113(2):207-221._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/27599751/">_x000D_ 10: Poveda J, Sanz AB, Fernandez-Fernandez B, Carrasco S, Ruiz-Ortega M,_x000D_ Cannata-Ortiz P, Ortiz A, Sanchez-Niño MD. MXRA5 is a TGF-β1-regulated human_x000D_ protein with anti-inflammatory and anti-fibrotic properties. J Cell Mol Med._x000D_ 2017 Jan;21(1):154-164. </a>_x000D_ _x000D_ <strong>Products Related to Human TWEAK Protein </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>