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Procyanidin B2 3,3'-di-O-gallate

Procyanidin B2, 3,3'-di-O-gallate is an active constituent. Procyanidin B2, 3,3'-di-O-gallate can be isolated from grape seed extract (GSE) procyanidin mix. Procyanidin B2, 3,3' -di-o-gallate target cancer stem cells (CSCs) in prostate cancer (PCa) . Procyanidin B2, 3,3'-di-O-gallate targets both unsorted and sorted CSCs at lower doses. Procyanidin B2, 3,3'-di-O-gallate strongly suppresses the constitutive as well as Jagged1 (Notch1 ligand) -induced activated Notch1 pathway[1].

Product Specifications

CAS Number

79907-44-1

UNSPSC

12352005

Target

Notch

Type

Natural Products

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/procyanidin-b2-3-3-di-o-gallate.html

Solubility

10 mM in DMSO

Smiles

O=C(C(C=C1O)=CC(O)=C1O)O[C@@H]([C@@H](C(C=C2)=CC(O)=C2O)OC3=CC(O)=C4)[C@@H](C(C(O)=C5)=C(O[C@H](C(C=C6)=CC(O)=C6O)[C@@H]7OC(C(C=C8O)=CC(O)=C8O)=O)C(C7)=C5O)C3=C4O

Molecular Formula

C44H34O20

Molecular Weight

882.73

References & Citations

[1]Tyagi A, Kumar S, Raina K, Wempe MF, Maroni PD, Agarwal R, Agarwal C. Differential effect of grape seed extract and its active constituent procyanidin B2 3,3″-di-O-gallate against prostate cancer stem cells. Mol Carcinog. 2019 Jul;58 (7) :1105-1117.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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