JTC-801

JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2 nM.

Product Specifications

CAS Number

[244218-51-7]

UNSPSC

12352005

Hazard Statement

H319, H413

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/JTC-801.html

Purity

98.91

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 0.33 mg/mL

Smiles

NC1=CC(C)=NC2=C1C=C(NC(C3=C(COC4=CC=C(C=C4)CC)C=CC=C3)=O)C=C2.[H]Cl

Molecular Formula

C26H26ClN3O2

Molecular Weight

447.96

Precautions

H319, H413

References & Citations

[1]Yamada H, et al. Pharmacological profiles of a novel opioid receptor-like1 (ORL (1) ) receptor antagonist, JTC-801. Br J Pharmacol, 2002, 135 (2), 323-332.|[2]Shinkai H, et al. 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. J Med Chem, 2000, 43 (24), 4667-4677.|[3]Zhang Y, et al. Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder. Br J Pharmacol. 2015 Jan;172 (2) :571-82.|[4]Koyama T, et al. Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice. J Anesth. 2009;23 (2) :301-3.