TfR-1-IN-1
TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC50 values of 0.51, 0.46, and 0.48 μM, respectively[1].
Product Specifications
CAS Number
1643444-62-5
UNSPSC
12352005
Target
Ferroptosis; Transferrin Receptor
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tfr-1-in-1.html
Purity
96.96
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
FC1=CC=CC2=C1C=[N]3C4=CC=CC=C4[N]5=CC6=C(F)C=CC=C6[O-][Fe+3]5([Cl-])3[O-]2
Molecular Formula
C20H12ClF2FeN2O2
Molecular Weight
441.62
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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