NS383
Product Specifications
UNSPSC Description
NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits[1].
Target Antigen
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ns383.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
O=C1NC2=C(CN(CC3)CC)C3=C(C4=CC=CC=C4)C=C2/C1=N/O
Molecular Weight
321.37
References & Citations
[1]Munro G, et al. NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats. CNS Neurosci Ther. 2016;22(2):135-145.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131879/NS383-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131879/NS383-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
309711-59-9
Available Sizes
Curated Selection
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