CPTH2
CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B) [1][2].
Product Specifications
CAS Number
357649-93-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cpth2.html
Purity
99.82
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 1 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1
Molecular Formula
C14H14ClN3S
Molecular Weight
291.80
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GCN5/PCAF
Available Sizes
Frequently Asked Questions
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