POL1-IN-1
POL1-IN-1 is a RNA polymerase 1 (POL1, also known as Pol I) inhibitor with an IC50 of less than 0.5 uM. POL1-IN-1 inhibits ribosome biogenesis by inhibiting POL1 transcription[1].
Product Specifications
CAS Number
[1822358-25-7]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pol1-in-1.html
Purity
98.05
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CC2=C(N3C1=NC4=CC=CC=C43)N=C(N5C[C@@H](C)N[C@@H](C)C5)C=C2
Molecular Formula
C21H20N6
Molecular Weight
356.42
References & Citations
[1]Mustapha Haddach. Compositions, uses and methods for making them. US9758518B2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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