ATM Inhibitor-11
ATM Inhibitor-11 (Compound 1) is an inhibitor for ATM with an IC50 of 0.32 nM. ATM Inhibitor-11 inhibits the KAP1 phosphorylation with an IC50 of 0.97 nM. ATM Inhibitor-11 exhibits high exposure in the brain, heart and plasma of ICR mouse. ATM Inhibitor-11 exhibits anti-tumor efficacy in NCI-H441 xenograft mouse model[1].
Product Specifications
CAS Number
[2878473-51-7]
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atm-inhibitor-11.html
Smiles
O=C1N(C)C2=C(N1C(C)C)C3=C(C=C(C(C4=CC=C(OCCCN5CCN(CC5)C)N=C4)=C3)F)N=C2
Molecular Formula
C27H33FN6O2
Molecular Weight
492.59
References & Citations
[1]Zhao C, et al., Heterocyclic compound and preparation method and application thereof. CN115304598A.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM
Explore Other Products
Browse additional items from our catalog
Lentiviral human CLEC9A shRNA (UAS) - Lentiviral human CLEC9A shRNA (UAS, RFP) plasmid