ATM Inhibitor-11
Product Specifications
UNSPSC Description
ATM Inhibitor-11 (Compound 1) is an inhibitor for ATM with an IC50 of 0.32 nM. ATM Inhibitor-11 inhibits the KAP1 phosphorylation with an IC50 of 0.97 nM. ATM Inhibitor-11 exhibits high exposure in the brain, heart and plasma of ICR mouse. ATM Inhibitor-11 exhibits anti-tumor efficacy in NCI-H441 xenograft mouse model[1].
Target Antigen
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atm-inhibitor-11.html
Smiles
O=C1N(C)C2=C(N1C(C)C)C3=C(C=C(C(C4=CC=C(OCCCN5CCN(CC5)C)N=C4)=C3)F)N=C2
Molecular Weight
492.59
References & Citations
[1]Zhao C, et al., Heterocyclic compound and preparation method and application thereof. CN115304598A.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169310/ATM-Inhibitor-11-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169310/
Clinical Information
No Development Reported
CAS Number
2878473-51-7
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