KCN1
KCN1 is a p300/HIF-1α interaction inhibitor. KCN1 inhibits HIF transcriptional activity by binding to the CH1 domain of p300 and preventing the p300/HIF-1α assembly. KCN1 exerts antitumor activities through cell cycle arrest[1][2].
Product Specifications
CAS Number
927823-01-6
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kcn1.html
Smiles
O=S(C1=CC=C(C(OC)=C1)OC)(N(C2=CC=CC=C2)CC3=CC4=C(C=C3)OC(C)(C)C=C4)=O
Molecular Formula
C26H27NO5S
Molecular Weight
465.56
References & Citations
[1]Shi Q, et al. Binding Model for the Interaction of Anticancer Arylsulfonamides with the p300 Transcription Cofactor. ACS Med Chem Lett. 2012 Jun 21;3 (8) :620-5. |[2]Wang W, et al. KCN1, a novel synthetic sulfonamide anticancer agent: in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. PLoS One. 2012;7 (9) :e44883.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300
Frequently Asked Questions
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