AV-412 (free base)
Product Specifications
UNSPSC Description
AV-412 free base (MP-412 free base) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AV-412-free-base.html
Purity
98.33
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C=C)NC1=CC2=C(NC3=CC=C(C(Cl)=C3)F)N=CN=C2C=C1C#CC(C)(C)N(CC4)CCN4C
Molecular Weight
507.00
References & Citations
[1]Suzuki T, et al. Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptorand ErbB2 tyrosine kinase inhibitor. Cancer Sci. 2007 Dec;98(12):1977-84.Science. 2017 Dec 1;358(6367):eaan4368.|Cancer Med. 2024 May;13(10):e7083.|Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005. |Sci Data. 2024 Sep 19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10346A/AV-412-free-base-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10346A/AV-412-free-base-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
451492-95-8
Available Sizes
Curated Selection
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