YTK-105
YTK-105 is a ligand of p62-ZZ domain. YTK-105 can activate p62-dependent selective macroautophagy. YTK-105 can be used for AUTOTAC design[1].
Product Specifications
CAS Number
774192-20-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P62
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ytk-105.html
Purity
98.81
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
OCCNCC1=CC=CC(OCC2=CC=CC=C2)=C1
Molecular Formula
C16H19NO2
Molecular Weight
257.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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