YTK-105

YTK-105 is a ligand of p62-ZZ domain. YTK-105 can activate p62-dependent selective macroautophagy. YTK-105 can be used for AUTOTAC design[1].

Product Specifications

CAS Number

[774192-20-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

P62

Type

Reference compound

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ytk-105.html

Purity

98.81

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

OCCNCC1=CC=CC(OCC2=CC=CC=C2)=C1

Molecular Formula

C16H19NO2

Molecular Weight

257.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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