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PPARα agonist 2

PPARα agonist 2 (compound 4u) is a potent and selective PPARα agonist with an EC50 of 37 nM. PPARα agonist 2 exhibits >2,700-fold selectivity for PPARα over other PPAR isoforms. PPARα agonist 2 has the potential for retinal disorders research[1].

Product Specifications

CAS Number

2376590-40-6

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pparα-agonist-2.html

Purity

98.9

Smiles

O=C(O)C1=CC=CC(NCC2=CC=C(OCC3=CC=C(F)C=C3)C(C)=C2)=C1

Molecular Formula

C22H20FNO3

Molecular Weight

365.40

References & Citations

[1]Xiaozheng Dou, et al. Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders. J Med Chem. 2020 Mar 26;63 (6) :2854-2876.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PPARα

Available Sizes

Frequently Asked Questions

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