PPARα agonist 2
PPARα agonist 2 (compound 4u) is a potent and selective PPARα agonist with an EC50 of 37 nM. PPARα agonist 2 exhibits >2,700-fold selectivity for PPARα over other PPAR isoforms. PPARα agonist 2 has the potential for retinal disorders research[1].
Product Specifications
CAS Number
2376590-40-6
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pparα-agonist-2.html
Purity
98.9
Smiles
O=C(O)C1=CC=CC(NCC2=CC=C(OCC3=CC=C(F)C=C3)C(C)=C2)=C1
Molecular Formula
C22H20FNO3
Molecular Weight
365.40
References & Citations
[1]Xiaozheng Dou, et al. Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders. J Med Chem. 2020 Mar 26;63 (6) :2854-2876.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα
Available Sizes
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