L82-G17
L82-G17 is an uncompetitive DNA ligase I (Lig I) -selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity[1].
Product Specifications
CAS Number
[92285-87-5]
UNSPSC
12352005
Hazard Statement
H302, H318
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l82-g17.html
Purity
99.59
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1NN=CC(N/N=C/C2=CC(O)=CC=C2)=C1Cl
Molecular Formula
C11H9ClN4O2
Molecular Weight
264.67
Precautions
H302, H318
References & Citations
[1]Timothy R L Howes, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst) . 2017 Dec;60:29-39.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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