L82-G17
Product Specifications
UNSPSC Description
L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity[1].
Target Antigen
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l82-g17.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1NN=CC(N/N=C/C2=CC(O)=CC=C2)=C1Cl
Molecular Weight
264.67
References & Citations
[1]Timothy R L Howes, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148161/L82-G17-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148161/L82-G17-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
92285-87-5
Available Sizes
Curated Selection
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