L82-G17

L82-G17 is an uncompetitive DNA ligase I (Lig I) -selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity[1].

Product Specifications

CAS Number

[92285-87-5]

UNSPSC

12352005

Hazard Statement

H302, H318

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l82-g17.html

Purity

99.59

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1NN=CC(N/N=C/C2=CC(O)=CC=C2)=C1Cl

Molecular Formula

C11H9ClN4O2

Molecular Weight

264.67

Precautions

H302, H318

References & Citations

[1]Timothy R L Howes, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst) . 2017 Dec;60:29-39.