M-PEG10-acid

M-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Product Specifications

CAS Number

[2409969-94-2]

UNSPSC

12352203

Hazard Statement

H315, H319

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m-peg10-acid.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O

Molecular Formula

C22H44O12

Molecular Weight

500.58

Precautions

H315, H319

References & Citations

[1]John F. Donovan et al. Pegylated prodrugs of phenolic trpv1 agonists. WO2020023794A1.|[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.