Hsp110-STAT3 PPI-IN-1
Row174336 (compound 29) is a potent inhibitor of Hsp110-STAT3 interaction that shows antiproliferative activity against HPAEC cell line, with the IC50 of 22.67 μM[1].
Product Specifications
CAS Number
882582-26-5
UNSPSC
12352005
Target
HSP; STAT
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/hsp110-stat3-interaction-in-1.html
Purity
90
Smiles
O=C(C1=CC(OCCC(C)C)=CC=C1)NC2=CC=C(S(=O)(N3CCN(CC3)C)=O)C=C2
Molecular Formula
C23H31N3O4S
Molecular Weight
445.58
References & Citations
[1]Congke Zhao, et al. Allosteric site identification, virtual screening and discovery of a sulfonamide Hsp110-STAT3 interaction inhibitor for the treatment of hypoxic pulmonary arterial hypertension. Eur J Med Chem. Q12024 Sep 7:279:116855.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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