Dibenzothiophene
Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with a Km of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740) . Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms[1][2].
Product Specifications
CAS Number
[132-65-0]
Product Name Alternative
DBT; Diphenylene sulfide
UNSPSC
12352005
Hazard Statement
H302, H410
Target
Aryl Hydrocarbon Receptor; Cytochrome P450
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Dibenzothiophene.html
Purity
99.98
Solubility
DMSO : 75 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C12=CC=CC=C1C3=CC=CC=C3S2
Molecular Formula
C12H8S
Molecular Weight
184.26
Precautions
H302, H410
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0973/Dibenzothiophene-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0973/Dibenzothiophene-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1
Available Sizes
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