Cynaropicrin
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
Product Specifications
CAS Number
35730-78-0
UNSPSC
12352005
Hazard Statement
H317
Target
MMP; NF-κB; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Cynaropicrin.html
Concentration
10mM
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=C([C@H]1O)[C@]([C@@]2([H])C1)([H])[C@](OC3=O)([H])[C@@](C3=C)([H])[C@@H](OC(C(CO)=C)=O)CC2=C
Molecular Formula
C19H22O6
Molecular Weight
346.37
Precautions
H317
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MMP-13; NF-κB; TNFRSF5/CD40
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Mouse Myosin Heavy Chain 2, Skeletal Muscle, Adult (MYH2) ELISA Kit
Mouse Myosin Heavy Chain 2, Skeletal Muscle, Adult (MYH2) ELISA Kit
