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CDK12-IN-6

CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 1.19 μM at high ATP (2 mM) . CDK12-IN-6 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1) [1].

Product Specifications

CAS Number

2651196-71-1

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk12-in-6.html

Purity

98.09

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=C2C(N=C(CNC3=NC(N4CCNCC4)=NC5=C(C6CC6)C=NN53)N2)=CC=C1F

Molecular Formula

C20H21F2N9

Molecular Weight

425.44

References & Citations

[1]Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK12; CDK2; CDK9

Available Sizes

Frequently Asked Questions

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