CDK12-IN-6
CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 1.19 μM at high ATP (2 mM) . CDK12-IN-6 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1) [1].
Product Specifications
CAS Number
[2651196-71-1]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk12-in-6.html
Purity
98.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C2C(N=C(CNC3=NC(N4CCNCC4)=NC5=C(C6CC6)C=NN53)N2)=CC=C1F
Molecular Formula
C20H21F2N9
Molecular Weight
425.44
References & Citations
[1]Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12; CDK2; CDK9
Available Sizes
Curated Selection
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