DAP Kinase 1 Recombinant Mouse Monoclonal Antibody [12B2-R]
Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene. Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. In melanocytic cells DAPK1 gene expression may be regulated by MITF. Depletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor-negative breast cancer, from individuals with p53-mutant cancers. This has not been demonstrated in actual patients.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
DAPK1, DAPK
Swiss Prot
P53355 Human
Cellular Locus
Cytoplasm, cytoskeleton.
Host
Mouse
Species Reactivity
Human
Immunogen
Recombinant protein within human DAP Kinase 1 aa 451-700 / 1,430.
Isotype
IgG1
Clone
12B2-R
Conjugation
Non-conjugated
Type
Recombinant Mouse monoclonal Antibody
Applications
WB, IHC-P
Positive Control
A549 cell lysate, TF-1 cell lysate, HepG2 cell lysate, human brain tissue lysate, human lung carcinoma tissue.
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IHC-P: 1:2,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 160 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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