(R) - (-) -Ibuprofen-d3
(R) - (-) -Ibuprofen-d3 is the deuterium labeled (R) - (-) -Ibuprofen. (R) - (-) -Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R) - (-) -Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
Product Specifications
CAS Number
121702-86-1
Product Name Alternative
(R) -Ibuprofen-d3
UNSPSC
12352005
Target
Isotope-Labeled Compounds; NF-κB
Type
Isotope-Labeled Compounds
Related Pathways
NF-κB; Others
Field of Research
Inflammation/Immunology; Cancer
Purity
99.96
Solubility
10 mM in DMSO|DMF : ≥ 45mg/mL|DMSO : ≥ 50mg/mL|Ethanol : ≥ 60mg/mL
Smiles
OC([C@@H](C1=CC=C(C=C1)CC(C)C)C([2H])([2H])[2H])=O
Molecular Formula
C13H15D3O2
Molecular Weight
209.30
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Evans AM, et al. Comparative pharmacology of S (+) -ibuprofen and (RS) -ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.|[3]Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123 (4) :645-52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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