Lufotrelvir
Product Specifications
UNSPSC Description
Lufotrelvir (PF-07304814), a phosphate proagent of PF-00835231, acts as a potent 3CLpro protease (Mpro) inhibitor with SARS-CoV-2 antiviral activity. Lufotrelvir binds and inhibits SARS-CoV-2 3CLpro activity with a Ki of 174nM. Lufotrelvir is promising single antiviral agent and also can be used for the research of combination with other antivirals that target other critical stages of the coronavirus life cycle.
Target Antigen
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pf-07304814.html
Smiles
COC1=C(C=C2C(N[C@@H](CC(C)C)C(N[C@H](C(CO[P](O)(O)=O)=O)C[C@H](CCN3)C3=O)=O)=O)C(N2)=CC=C1
Molecular Weight
552.51
References & Citations
[1]Koen Vandyck, et al. Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection. Curr Opin Virol. 2021 Apr 27;49:36-40.|[2]Britton Boras, et al. Title: Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19 Short Title: Novel 3CL Protease Inhibitor for COVID-19
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-138078/Lufotrelvir-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-138078/Lufotrelvir-SDS-MedChemExpress.pdf
CAS Number
2468015-78-1
Available Sizes
Curated Selection
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