FXIa-IN-14
FXIa-IN-14 (Compound 14c) is a FXIa inhibitor with an IC50 value of 15 nM[1].
Product Specifications
CAS Number
2423992-72-5
UNSPSC
12352005
Target
Factor Xa
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fxia-in-14.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC2=C(NC(C=C2CN(C([C@H](CC3=CC=C(NC(C4C(C)C4)=O)C=C3)NC(C5=CC=C(C(O)=O)S5)=O)=O)C)=O)C=C1
Molecular Formula
C31H29ClN4O6S
Molecular Weight
621.10
References & Citations
[1]Wang Y, et al. Design, synthesis and biological evaluation of 6-chloro-quinolin-2-one derivatives as novel FXIa inhibitors. Bioorg Med Chem Lett. 2024 Jan 9;99:129610.|[2]Wang Y, et al. Design, synthesis and biological evaluation of 6-chloro-quinolin-2-one derivatives as novel FXIa inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2024, 99: 129610.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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