ZK 187638

ZK 187638 is an AMPA receptor antagonist. ZK 187638 antagonizes the kainate-induced currents in cultured hippocampal neurons with an IC50 of 3.4 μM in a noncompetitive fashion[1].

Product Specifications

CAS Number

[397298-63-4]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zk-187638.html

Smiles

CC1=C(C)N=C2CC3=C(C=C4OCOC4=C3)C(C5=CC=CC=C5)=NN12

Molecular Formula

C20H17N3O2

Molecular Weight

331.37

References & Citations

[1]Bernd Elger, et al. Novel alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor antagonists of 2,3-benzodiazepine type: chemical synthesis, in vitro characterization, and in vivo prevention of acute neurodegeneration. J Med Chem. 2005 Jul 14;48 (14) :4618-27.