ZK 187638
ZK 187638 is an AMPA receptor antagonist. ZK 187638 antagonizes the kainate-induced currents in cultured hippocampal neurons with an IC50 of 3.4 μM in a noncompetitive fashion[1].
Product Specifications
CAS Number
397298-63-4
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zk-187638.html
Smiles
CC1=C(C)N=C2CC3=C(C=C4OCOC4=C3)C(C5=CC=CC=C5)=NN12
Molecular Formula
C20H17N3O2
Molecular Weight
331.37
References & Citations
[1]Bernd Elger, et al. Novel alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor antagonists of 2,3-benzodiazepine type: chemical synthesis, in vitro characterization, and in vivo prevention of acute neurodegeneration. J Med Chem. 2005 Jul 14;48 (14) :4618-27.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940253-100 1x 100 µL
Cytokeratin, LMW (AE-1), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400050-500 1x 500 µL
IgA Secretory Component (SC05), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880204-100 1x 100 µL
Complement C4d (C4D204), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740812-500 1x 500 µL
Tyrosinase (OCA1/812), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940197-500 1x 500 µL
FOXP3 (FXP3/197), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details