SUCNR1-IN-1

SUCNR1-IN-1 (Compound 20) is a SUCNR1 inhibitor (IC50: 88 nM for hSUCNR1) . SUCNR1-IN-1 can be used for research of rheumatoid arthritis, liver fibrosis, or obesity[1].

Product Specifications

CAS Number

[2711753-52-3]

UNSPSC

12352005

Target

Succinate Receptor 1

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sucnr1-in-1.html

Purity

99.39

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=CC(Cl)=C(O[C@@H]2CCCNC2)C=C1C3=C(C(C(NC4=C(C=C(C=C4)F)CC(O)=O)=O)=CC=C3)F

Molecular Formula

C26H22ClF3N2O4

Molecular Weight

518.91

References & Citations

[1]Velcicky J, et al. Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure. J Med Chem. 2020 Sep 10;63 (17) :9856-9875.