(R) -MG-132

(R) -MG-132 ((S, R, S) - (-) -MG-132) is the enantiomer of MG-132. (R) -MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132[1].

Product Specifications

CAS Number

[1211877-36-9]

Product Name Alternative

(S, R, S) - (-) -MG-132; Z-Leu-D-Leu-Leu-al

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-mg-132.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](CC(C)C)C(N[C@@H](CC(C)C)C=O)=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O

Molecular Formula

C26H41N3O5

Molecular Weight

475.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Mroczkiewicz M, et al. Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach. J Med Chem. 2010 Feb 25;53 (4) :1509-18.