Levetiracetam-d6
Levetiracetam-d6 is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].
Product Specifications
CAS Number
1133229-29-4
Product Name Alternative
UCB L059-d6
UNSPSC
12352005
Target
DNA Methyltransferase; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Epigenetics; Others
Field of Research
Cancer; Neurological Disease
Solubility
10 mM in DMSO
Smiles
[C@](C(N)=O)(C(C([2H])([2H])[2H])([2H])[2H])(N1C(=O)CCC1)[2H]
Molecular Formula
C₈H₈D₆N₂O₂
Molecular Weight
176.25
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Bianca Maria Scicchitano, et al. Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Cancer Cell Int. 2018 Sep 10;18:136.|[3]Delia M Talos, et al. Antiepileptic effects of levetiracetam in a rodent neonatal seizure model. Pediatr Res. 2013 Jan;73 (1) :24-30.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC040017-500 1x 500 µL
Ep-CAM / CD326 (VU-1D9), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC041231-500 1x 500 µL
Eosinophil Peroxidase (AHE-1), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 