2-Linoleoyl glycerol
2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 , an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG)[2].
Product Specifications
CAS Number
3443-82-1
Product Name Alternative
2-Monolinolein; 2-Monolinoleoylglycerol
UNSPSC
12352211
Hazard Statement
H225, H302+H312+H332, H319
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-linoleoyl-glycerol.html
Concentration
14.10 mM * 200 μL in Methyl acetate
Purity
99.9
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\C/C=C\CCCCCCCC(OC(CO)CO)=O
Molecular Formula
C21H38O4
Molecular Weight
354.52
Precautions
H225, H302+H312+H332, H319
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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