2-Linoleoyl glycerol

2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG) [1][2].

Product Specifications

CAS Number

[3443-82-1]

Product Name Alternative

2-Monolinolein; 2-Monolinoleoylglycerol

UNSPSC

12352211

Hazard Statement

H225, H302+H312+H332, H319

Target

Cannabinoid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-linoleoyl-glycerol.html

Concentration

14.10 mM * 200 μL in Methyl acetate

Purity

99.9

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\C/C=C\CCCCCCCC(OC(CO)CO)=O

Molecular Formula

C21H38O4

Molecular Weight

354.52

Precautions

H225, H302+H312+H332, H319

References & Citations

[1]Lu L, et al. 2-Linoleoylglycerol is a partial agonist of the human cannabinoid type 1 receptor that can suppress 2-arachidonolyglycerol and anandamide activity[J]. Cannabis and cannabinoid research, 2019, 4 (4) : 231-239.|[2]Sugiura T, et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastomax glioma hybrid NG108-15 cells[J]. Biochemical and biophysical research communications, 1996, 229 (1) : 58-64.