Hemoglobin Protease Substrate

<strong>Hemoglobin Protease Substrate</strong>_x000D_ <strong>Catalog number:</strong> B2013002_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 g_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Hemoglobin from bovine blood, Bovine hemoglobin, Hb, Methemoglobin_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ. The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9138-43._x000D_ 2: Singh V, Hada RS, Uddin A, Aneja B, Abid M, Pandey KC, Singh S. Inhibition of Hemoglobin Degrading Protease Falcipain-2 as a Mechanism for Anti-Malarial Activity of Triazole-Amino Acid Hybrids Curr Top Med Chem. 2020;20(5):377-389._x000D_ 3: De Lumen BO, Tappel AL. Fluorescein-hemoglobin as a substrate for cathepsin D and other proteases Anal Biochem. 1970 Jul;36(1):22-9._x000D_ 4: Sharma A, Eapen A, Subbarao SK. Purification and characterization of a hemoglobin degrading aspartic protease from the malarial parasite Plasmodium vivax J Biochem. 2005 Jul;138(1):71-8._x000D_ 5: Arcoleo JP, Greer J. Hemoglobin binding site and its relationship to the serine protease-like active site of haptoglobin J Biol Chem. 1982 Sep 10;257(17):10063-8._x000D_ 6: Pasupureddy R, Verma S, Pant A, Sharma R, Seshadri S, Pande V, Saxena AK, Dixit R, Pandey KC. Crucial residues in falcipains that mediate hemoglobin hydrolysis Exp Parasitol. 2019 Feb;197:43-50._x000D_ 7: Junaid MA, Brooks SS, Pullarkat RK. Specific substrate for CLN2 protease/tripeptidyl-peptidase I assay Eur J Paediatr Neurol. 2001;5 Suppl A:63-8._x000D_ 8: Williams HR, Lin TY. Methyl- 14 C-glycinated hemoglobin as a substrate for proteases Biochim Biophys Acta. 1971 Dec 15;250(3):603-7._x000D_ 9: Istvan ES, Goldberg DE. Distal substrate interactions enhance plasmepsin activity J Biol Chem. 2005 Feb 25;280(8):6890-6._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/2007860">10: Goldberg DE, Slater AF, Beavis R, Chait B, Cerami A, Henderson GB. Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease J Exp Med. 1991 Apr 1;173(4):961-9. </a>_x000D_ _x000D_ <strong>Products Related to Hemoglobin Protease Substrate can be found at</strong> <a href="https://moleculardepot.com/product-category/Substrates/"> Substrates</a>