Sulfo-SPDB
Sulfo-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
1193111-39-5
UNSPSC
12352203
Hazard Statement
H302, H319
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sulfo-spdb.html
Purity
95.0
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C(ON1C(CCC1=O)=O)C(S(=O)(O)=O)CCSSC2=NC=CC=C2
Molecular Formula
C13H14N2O7S3
Molecular Weight
406.45
Precautions
H302, H319
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light, stored under nitrogen
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker
Available Sizes
Frequently Asked Questions
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