Anti-Glucose transporter 2 Antibody

Rabbit Polyclonal Antibody specific to Glucose transporter 2

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Glucose transporter type 2, liver, GLUT-2

Gene Name

SLC2A2

NCBI Gene ID

UniProt

P11168

Cellular Locus

Cell membrane, Multi-pass membrane protein

Host

Rabbit

Reactivity

Human, Rat

Immunogen

Synthetic peptide corresponding to the C-terminus of human GLUT2.

Target Antigen

Solute carrier family 2, facilitated glucose transporter member 2

Target

Glucose transporter 2

Clonality

Polyclonal

Type

Antibody

Applications

WB, ICC/IF

Field of Research

Neuroscience

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

1.0 mg/mL

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:8027028, PubMed:16186102, PubMed:23396969, PubMed:28083649). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). {PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:3399500, PubMed:8027028}.

Additionnal Information

Immunoblotting: use at dilution of 1:1,000. A bands of 57~kDa is detected. Bands of ~72kDa and ~37kDa may also be detected. Immunofluorescence: use at dilution of 1:100 These are recommended working dilutions. Endusers should determine optimal dilutions for their applications.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Specificity

This antibody recognizes human and rat GLUT2..

Formulation

PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.

Buffer pH

pH 7.4

Target Background

GLUT2 is a member of the human glucose transport protein family. It is present in high concentration in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion. GLUT2 is required for glucose sensitivity in the hypothalamus and brain stem and is involved in control of food intake and stimulation of glucose uptake by peripheral tissues.