Isomannide

Isomannide (1,4:3,6-Dianhydromannitol) is a common intermediate compound and derivative of Isosorbide (HY-B1469) . Some derivatives of isomannide have potent inhibitory effects on KLK5 and KLK7. Isomannide can be used in the research of HCV infection and KLK5/KLK7-related diseases[1][2][3].

Product Specifications

CAS Number

[641-74-7]

Product Name Alternative

1,4:3,6-Dianhydromannitol

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents; Drug Derivative; Drug Intermediate

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/isomannide.html

Purity

99.97

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O[C@H]1[C@]2([H])[C@@](OC1)([H])[C@@H](CO2)O

Molecular Formula

C6H10O4

Molecular Weight

146.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Rose M, et al. Isosorbide as a renewable platform chemical for versatile applications--quo vadis? ChemSusChem. 2012 Jan 9;5 (1) :167-76.|[2]Barros TG, et al. Pseudo-peptides derived from isomannide: inhibitors of serine proteases. Amino Acids. 2010 Mar;38 (3) :701-9.|[3]Oliveira JP, et al. Isomannide-based peptidomimetics as inhibitors for human tissue kallikreins 5 and 7. ACS Med Chem Lett. 2013 Dec 6;5 (2) :128-32.