WZ-3146
WZ3146 is a mutant selective EGFR inhibitor with IC50s of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750, EGFRE746_A750/T790M and EGFR, respectively.
Product Specifications
CAS Number
1214265-56-1
UNSPSC
12352005
Hazard Statement
H317, H319
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wz-3146.html
Purity
99.28
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN1CCN(C2=CC=C(C=C2)NC3=NC=C(C(OC4=CC(NC(C=C)=O)=CC=C4)=N3)Cl)CC1
Molecular Formula
C24H25ClN6O2
Molecular Weight
464.95
Precautions
H317, H319
References & Citations
[1]Zhou W, et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.Nature. 2009 Dec 24;462 (7276) :1070-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
![SFT Recombinant Rabbit Monoclonal Antibody [JE64-46]](https://cdn.genprice.uk/products/992/68dd1c8e061270361ea82318/imageurl/ha722578.webp)
SFT Recombinant Rabbit Monoclonal Antibody [JE64-46]
MUC2 (Mucin 2) (rMLP/842), CF594 conjugate, 0.1mg/mL
GLUT-1 (Tumor Progression and Mesothelioma Marker) (GLUT1/3132R), Biotin conjugate, 0.1mg/mL
![Elab Fluor® 700 Anti-Mouse MHC II (I-A/I-E) Antibody[M5/114]](https://cdn.genprice.uk/products/763/68dd14a4061270361e7d1409/imageurl/e-ab-f0990m1.webp)