Ac-VAD-AFC

Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases[1][2].

Product Specifications

UNSPSC

12352209

Target

Caspase

Type

Peptides

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ac-vad-afc.html

Solubility

10 mM in DMSO

Smiles

O=C1OC2=C(C=C1C(F)(F)F)C=CC(NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)C(C)C)=O)C)=O)CC(O)=O)=O)=C2

Molecular Formula

C24H27F3N4O8

Molecular Weight

556.49

References & Citations

[1]Choi WS, et al. Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2. J Neurochem. 2001;77 (6) :1531-1541.|[2]Posadas I, et al. Acetaminophen induces human neuroblastoma cell death through NFKB activation. PLoS One. 2012;7 (11) :e50160.