CDD-1653
CDD-1653 is a potent and selective BMPR2 inhibitor (IC50=2.8 nM) . CDD-1653 reduces the ability of ATP to bind to the kinase domain of BMPR2, thereby affecting the phosphorylation of SMAD1/5/8 transcription factors, which play a key role in the BMP signaling pathway. CDD-1653 can be used to study diseases related to the BMP signaling pathway[1].
Product Specifications
CAS Number
3034216-44-6
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Others
Assay Protocol
https://www.medchemexpress.com/cdd-1653.html
Concentration
10mM
Purity
99.38
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(CCN(C1)C2=NC(NC3=CC=CC(S(=O)(N)=O)=C3)=NC=C2OC)C4=CC=CC=C4
Molecular Formula
C21H22N6O4S
Molecular Weight
454.50
References & Citations
[1]Modukuri R K, et al. Discovery of highly potent and BMPR2-selective kinase inhibitors using DNA-encoded chemical library screening[J]. Journal of Medicinal Chemistry, 2023, 66 (3) : 2143-2160.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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