11R-VIVIT (TFA)
11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy[1].
Product Specifications
Product Name Alternative
Cell permeable NFAT inhibitor (TFA)
UNSPSC
12352209
Target
Nuclear Factor of activated T Cells (NFAT)
Type
Peptides
Related Pathways
Immunology/Inflammation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/11r-vivit-tfa.html
Purity
99.71
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(CCC1)C(CNC([C@H](C)NC([C@H](CCSC)NC(CNC(CNC(CNC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(NCC(N4[C@@H](CCC4)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CCC(O)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
Molecular Formula
C147H259N67O36S
Molecular Weight
3573.15
References & Citations
[1]Zhang L, et al. NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice. Br J Pharmacol. 2013;170 (2) :426-439.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Acta Pharmacol Sin. 2022 Aug;43 (8) :2081-2093.|Am J Respir Cell Mol Biol. 2023 Mar;68 (3) :256-266.|Cell Rep Med. 2025 Jan 16:101922.|CNS Neurosci Ther. 2025 Feb;31 (2) :e70222.|bioRxiv. May 18, 2022.|Elife. 2022 Aug 22;11:e79957.|Inflammopharmacology. 2023 Oct;31 (5) :2431-2443.|Research Square Preprint. 2021 Oct.
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