Promethazine (hydrochloride)

Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors[1][2].

Product Specifications

CAS Number

[58-33-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H332, H335, H411

Target

Adrenergic Receptor; Histamine Receptor; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Promethazine-hydrochloride.html

Purity

99.85

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CC(N(C)C)CN1C(C=CC=C2)=C2SC3=CC=CC=C13.[H]Cl

Molecular Formula

C17H21ClN2S

Molecular Weight

320.88

Precautions

H302, H315, H319, H332, H335, H411

References & Citations

[1]Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl) . 1995 Oct;121 (3) :347-56.|[2]Kasai T, et al. Promethazine Hydrochloride Inhibits Ectopic Fat Cell Formation in Skeletal Muscle. Am J Pathol. 2017 Dec;187 (12) :2627-2634.|[3]McDonough JA, et al. Microcapsule-gel formulation of promethazine HCl for controlled nasal delivery: a motion sickness medication. J Microencapsul. 2007 Mar;24 (2) :109-16. |[4]Wink CS, et al. Effects of promethazine HCl on osteoporotic femora of adult castrated male rats. Acta Anat (Basel) .