CCR7 Ligand 1

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM[1].

Product Specifications

CAS Number

[681514-83-0]

Product Name Alternative

CCR7-Cmp2105

UNSPSC

12352005

Target

CCR; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ccr7-ligand-1.html

Purity

99.19

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C)C)C1=C(C)C=CC(NC(C(N[C@@H](C2=CC=C(C)O2)C(C)(C)C)=N3)=NS3(=O)=O)=C1O

Molecular Formula

C22H29N5O5S

Molecular Weight

475.56

References & Citations

[1]Jaeger K, et al. Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7. Cell. 2019 Aug 22;178 (5) :1222-1230.e10.