CCR7 Ligand 1
CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM[1].
Product Specifications
CAS Number
681514-83-0
Product Name Alternative
CCR7-Cmp2105
UNSPSC
12352005
Target
CCR; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ccr7-ligand-1.html
Purity
99.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(C)C)C1=C(C)C=CC(NC(C(N[C@@H](C2=CC=C(C)O2)C(C)(C)C)=N3)=NS3(=O)=O)=C1O
Molecular Formula
C22H29N5O5S
Molecular Weight
475.56
References & Citations
[1]Jaeger K, et al. Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7. Cell. 2019 Aug 22;178 (5) :1222-1230.e10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR7
Available Sizes
Frequently Asked Questions
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