FT3967385

FT3967385 is a novel USP30 inhibitor that recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.

Product Specifications

Product Name Alternative

FT385

UNSPSC

12352005

Target

Deubiquitinase; PINK1/Parkin

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ft3967385.html

Concentration

10mM

Purity

99.74

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H]1CN(C#N)CC1)C2=CC(C3=C(OC4=CC=CC=C4)C=CC=C3)=NN2

Molecular Formula

C21H19N5O2

Molecular Weight

373.41

References & Citations

[1]Rusilowicz-Jones E, et al. A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation. BioRxiv. 2020 April 20.