X-376 (Standard)
X-376 (Standard) is the analytical standard of X-376. This product is intended for research and analytical applications. X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0.61 nM) . X-376 is a less potent inhibitor of MET (IC50=0.69 nM) . X-376 displays potent anti-tumor activity[1].
Product Specifications
CAS Number
[1365267-27-1]
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; c-Met/HGFR; Reference Standards
Type
Reference Standards
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/x-376-standard.html
Smiles
O=C(C1=NN=C(N)C(O[C@@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4CCN(C)CC4)=O)C=C3
Molecular Formula
C25H25Cl2FN6O3
Molecular Weight
547.41
References & Citations
[1]Lovly CM, et al. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinaseinhibitors. Cancer Res. 2011 Jul 15;71 (14) :4920-31.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![FLT4 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI8C2]](https://cdn.genprice.uk/products/937/6868c3d7994c49e6dc40002f/imageurl/ta807002bm.webp)
TA807002BM 100 µL
FLT4 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI8C2]
Ask
View Details 
MBS6379677-01 0.1 mL
GDI1 (Guanosine Diphosphate Dissociation Inhibitor 1, GDP Dissociation Inhibitor 1, GDI-1, FLJ41411, GDIL, MRX41, MRX48, Oligophrenin-2, OPHN2, Protein XAP-4, Rab GDP Dissociation Inhibitor alpha, Rab GDI alpha, RABGDIA, XAP4) (MaxLight 550)
Ask
View Details 
MBS6379677-02 5x 0.1 mL
GDI1 (Guanosine Diphosphate Dissociation Inhibitor 1, GDP Dissociation Inhibitor 1, GDI-1, FLJ41411, GDIL, MRX41, MRX48, Oligophrenin-2, OPHN2, Protein XAP-4, Rab GDP Dissociation Inhibitor alpha, Rab GDI alpha, RABGDIA, XAP4) (MaxLight 550)
Ask
View Details