X-376 (Standard)

X-376 (Standard) is the analytical standard of X-376. This product is intended for research and analytical applications. X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0.61 nM) . X-376 is a less potent inhibitor of MET (IC50=0.69 nM) . X-376 displays potent anti-tumor activity[1].

Product Specifications

CAS Number

[1365267-27-1]

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK) ; c-Met/HGFR; Reference Standards

Type

Reference Standards

Related Pathways

Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/x-376-standard.html

Smiles

O=C(C1=NN=C(N)C(O[C@@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4CCN(C)CC4)=O)C=C3

Molecular Formula

C25H25Cl2FN6O3

Molecular Weight

547.41

References & Citations

[1]Lovly CM, et al. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinaseinhibitors. Cancer Res. 2011 Jul 15;71 (14) :4920-31.