Columbin (Standard)

Columbin (Standard) is the analytical standard of Columbin. This product is intended for research and analytical applications. Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) [1][2].

Product Specifications

CAS Number

[546-97-4]

UNSPSC

12352005

Target

COX; Parasite; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/columbin-standard.html

Smiles

O=C1[C@](C=C2)(O)[C@@](CC3)(C)[C@@]([C@@](C[C@@H](C4=COC=C4)O5)(C)[C@]3([H])C5=O)([H])[C@]2([H])O1

Molecular Formula

C20H22O6

Molecular Weight

358.39

References & Citations

[1]Ibrahim Abdelwahab S, et al. In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-κB translocation. Eur J Pharmacol. 2012 Mar 5;678 (1-3) :61-70.|[2]A J Nok, et al. Columbin inhibits cholesterol uptake in bloodstream forms of Trypanosoma brucei-A possible trypanocidal mechanism.J Enzyme Inhib Med Chem. 2005 Aug;20 (4) :365-8.|[3]Yang G, et al. Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:13-8